tert-Butyl [(4-fluoro-3-nitrophenyl)methyl]carbamate → tert-Butyl [(3-amino-4-fluorophenyl)methyl]carbamate

HRID 2366746노트

반응식

HRID 2366746 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:4][C:3]=1[N+:17]([O-])=O>CO.[C].[Pd]>[NH2:17][C:3]1[CH:4]=[C:5]([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:14])([CH3:13])[CH3:15])[CH:6]=[CH:7][C:2]=1[F:1]

참가 물질

4

반응물 1

HCID 53420783tert-Butyl [(4-fluoro-3-nitrophenyl)methyl]carbamate

생성물 1

HCID 53439222tert-Butyl [(3-amino-4-fluorophenyl)methyl]carbamate수율 99%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

To a solution of tert-butyl (4-fluoro-3-nitrophenyl)methylcarbamate (1.0 g, 3.70 mmol) in methanol (4 mL) was added 10% palladium-carbon (150 mg), and the mixture was stirred at room temperature under a hydrogen atmosphere (1 atm) for 18 hr. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate), and the obtained solution was concentrated under reduced pressure to give the title compound (0.88 g, 99%) as a brown oil.

후처리

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate)
  4. concentrationthe obtained solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-07e0ed7db94c47ab8dba6276d4354dce
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697874B2

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