Pyridine → Methyl 3-acetyl-4-(2'-isopropoxy-5'-methyl-benzoyloxy)-benzoate

HRID 236700노트

반응식

HRID 236700 반응식
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[OH:14])[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2].[CH:15]([O:18][C:19]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:20]=1[C:21](Cl)=[O:22])([CH3:17])[CH3:16].N1C=CC=CC=1>O1CCOCC1>[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[O:14][C:21](=[O:22])[C:20]1[CH:24]=[C:25]([CH3:28])[CH:26]=[CH:27][C:19]=1[O:18][CH:15]([CH3:16])[CH3:17])[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 12332833Methyl 3-acetyl-4-hydroxybenzoateHCID 213157482-Isopropoxy-5-methyl-benzoyl chloride

생성물 1

HCID 21315729Methyl 3-acetyl-4-(2'-isopropoxy-5'-methyl-benzoyloxy)-benzoate수율 113.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Methyl 3-acetyl-4-hydroxy-benzoate (6 g) in dioxane (100 ml) was reacted with 2-isopropoxy-5-methyl-benzoyl chloride (10 g) in the presence of pyridine (10 ml) at room temperature for 16 hours. After dilution with water, the precipitate was extracted with ethyl acetate and the organic solution was washed with 5% NaHCO3 and water and then evaporated to dryness to give methyl 3-acetyl-4-(2'-isopropoxy-5'-methyl-benzoyloxy)-benzoate (13 g, oil), which was dissolved in methyl-ethyl-ketone (200 ml) and treated with anhydrous potassium carbonate (22 g) under stirring at the reflux temperature for 4 hours.

후처리

  1. extractionAfter dilution with water, the precipitate was extracted with ethyl acetate
  2. washthe organic solution was washed with 5% NaHCO3 and water
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-0b2b14dab56d4bab94d63009b1de3844
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04157334

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