2-Amino-4-chloropyrimidine → HCID 58504552, 화합물

HRID 2367199노트

반응식

HRID 2367199 반응식
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[C:6]([F:10])[C:7]=1[CH:8]=[O:9].Cl[C:15]1[CH:20]=[CH:19][N:18]=[C:17]([NH2:21])[N:16]=1>>[NH2:21][C:17]1[N:18]=[C:19]([C:4]2[CH:3]=[C:2]([F:1])[C:7]([CH:8]=[O:9])=[C:6]([F:10])[CH:5]=2)[CH:20]=[CH:15][N:16]=1

참가 물질

3

반응물 2

HCID 2233322-Amino-4-chloropyrimidineHCID 162177083,5-Difluoro-4-formylphenylboronic acid

생성물 1

HCID 58504552HCID 58504552, 화합물수율 91.3%

실험 절차

The title compound was prepared following the General Procedure A using: (3,5-difluoro-4-formylphenyl)boronic acid (4.93 g, 26.5 mmol) and 4-chloro-2-pyrimidinamine (3.44 g, 26.5 mmol). Flash chromatography on SiO2 (gradient: 100% CHCl3 to 10% THF/90% CHCl3) afforded the title compound (5.69 g, 75%) as an off-white solid. LC-MS (ES) m/z=236 [M+H]+.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-f9461ab8fb8044178dabbe0eb8e80936
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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