6-Chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamine → HCID 58504374, 화합물

HRID 2367207노트

반응식

HRID 2367207 반응식
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[C:6]([F:10])[C:7]=1[CH:8]=[O:9].Cl[C:15]1[N:20]=[C:19]([NH2:21])[N:18]=[C:17]([N:22]([CH3:24])[CH3:23])[CH:16]=1>CCOC(C)=O>[NH2:21][C:19]1[N:20]=[C:15]([C:4]2[CH:3]=[C:2]([F:1])[C:7]([CH:8]=[O:9])=[C:6]([F:10])[CH:5]=2)[CH:16]=[C:17]([N:22]([CH3:24])[CH3:23])[N:18]=1

참가 물질

4

반응물 2

HCID 2517356-Chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamineHCID 162177083,5-Difluoro-4-formylphenylboronic acid

생성물 1

HCID 58504374HCID 58504374, 화합물수율 80%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The title compound was prepared following the General Procedure A using: (3,5-difluoro-4-formylphenyl)boronic acid (2.37 g, 12.8 mmol) and 6-chloro-N4,N4-dimethyl-2,4-pyrimidinediamine (2.2 g, 12.8 mmol). The solid was dissolved in EtOAc and precipitated with hexanes. The resulting solid was collected via vacuum filtration to afford the title compound (2.82 g, 80%) as a yellow solid. LC-MS (ES) m/z=279 [M+H]+.

후처리

  1. customThe title compound was prepared
  2. customprecipitated with hexanes
  3. filtrationThe resulting solid was collected via vacuum filtration

출처 및 근거

ORD 기록
ord-70a2ee2b89f1414c84b29acd83ab527d
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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