Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trityl chloride → Dimethyl 1-trityl-3,5-pyrazoledicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trityl chloride | HCID 6456 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3,5-dimethyl 1H-pyrazole-3,5-dicarboxylate | HCID 1484491 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| 생성물 | Dimethyl 1-trityl-3,5-pyrazoledicarboxylate | HCID 12377531 | — |
반응 단계
To a solution of 1.84 g. (10 mmol) of 3,5-pyrazoledicarboxylic acid dimethyl ester* in 15 ml. of DMF, stirred at 0° under argon, was added 480 mg. (10 mmol) of 50% NaH (suspension in mineral oil). After the evolution of hydrogen had ceased, 2.7 g. (10 mmol) of triphenylmethyl chloride in 20 ml. of DMF was added dropwise. The mixture was allowed to warm to room temperature, stirred 1.5 hours, poured into H2O, and the resulting precipitate filtered. After recrystallization from 2-ethoxyethanol-H2O, there was obtained the end product. The analytical sample was obtained as colorless needles by recrystallization from DMF-H2O; mp 212°-213.5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04157331 |
| 출처 데이터셋 | uspto-grants-1979_06 |
| ORD ID | ord-33f2f6c2ddd84ba9ae4205c636ff5b3b |
| 출처 메모 | uspto-grants-1979_06 |