(2S,5R)-5-Ethyl-4-(phenylmethyl)-2-morpholinemethanol → [(2S,5R)-5-Ethylmorpholin-2-yl]methanol

HRID 2367550노트

반응식

HRID 2367550 반응식
[CH2:1]([C@H:3]1[N:8](CC2C=CC=CC=2)[CH2:7][C@@H:6]([CH2:16][OH:17])[O:5][CH2:4]1)[CH3:2]>CO.[Pd]>[CH2:1]([C@H:3]1[NH:8][CH2:7][C@@H:6]([CH2:16][OH:17])[O:5][CH2:4]1)[CH3:2]

참가 물질

4

반응물 1

HCID 51357958(2S,5R)-5-Ethyl-4-(phenylmethyl)-2-morpholinemethanol

생성물 1

HCID 51354034[(2S,5R)-5-Ethylmorpholin-2-yl]methanol수율 100.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

[(2S,5R)-5-Ethyl-4-(phenylmethyl)-2-morpholinyl]methanol (0.5 g, 2.125 mmol) was dissolved in CH3OH (20 mL) and placed under a nitrogen atmosphere. Palladium on carbon (10 wt %, 0.023 g, 0.212 mmol) was added and the flask was flushed with nitrogen and evacuated (3×). Then the reaction was placed under an atmosphere of hydrogen (balloon), and stirred at room temperature overnight. The reaction mixture was filtered through celite and concentrated to afford the title compound (0.309 g) as a colorless oil. LC-MS (ES) m/z=146 [M+H]+.

후처리

  1. customthe flask was flushed with nitrogen
  2. customevacuated (3×)
  3. filtrationThe reaction mixture was filtered through celite
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-12226534b9bb46bcaacad048d0fab5b6
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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