1,2-Dichloroethane → HCID 51354039, 화합물

HRID 2367552노트

반응식

HRID 2367552 반응식
[CH3:1][C:2]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][CH3:15])[CH2:12][O:11][C@H:10]([C:16]([OH:18])=O)[CH2:9]1)=[O:7])([CH3:4])[CH3:3].[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1C=NC2N(O)N=NC=2C=1.C(Cl)CCl>C(Cl)Cl>[CH2:14]([C@H:13]1[N:8]([C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7])[CH2:9][C@@H:10]([C:16]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[O:11][CH2:12]1)[CH3:15]

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 6115AnilineHCID 181649HOAtHCID 51356009HCID 51356009, 화합물

생성물 1

HCID 51354039HCID 51354039, 화합물수율 76.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (2S,5R)-4-{[(1,1-dimethylethyl)oxy]carbonyl}-5-ethyl-2-morpholinecarboxylic acid (0.250 g, 0.964 mmol) in CH2Cl2 (10 mL) were added aniline (0.088 mL, 0.964 mmol), HOAt (0.131 g, 0.964 mmol) and EDC (0.222 g, 1.157 mmol), and the reaction mixture was stirred at room temperature overnight. The reaction mixture was washed with water (2×), and the organics were dried over Na2SO4 and concentrated to afford the title compound (0.247 g) as a brown oil. LC-MS (ES) m/z=240 [M+H]+.

후처리

  1. washThe reaction mixture was washed with water (2×)
  2. dry with materialthe organics were dried over Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-53738a7a311f4cc29a4f1c12d9588519
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697685B2

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