Diethyl 2-((2-bromo-4-cyanophenylamino)methylene)malonate → HCID 178469455, 화합물

HRID 2367656노트

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HRID 2367656 반응식
[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:11]=[C:12]([C:18]([O:20]CC)=O)[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C1(OC2C=CC=CC=2)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]2[C:3]=1[N:10]=[CH:11][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:18]2[OH:20]

참가 물질

3

반응물 1

HCID 66823182Diethyl 2-((2-bromo-4-cyanophenylamino)methylene)malonate

생성물 1

HCID 178469455HCID 178469455, 화합물수율 130.3%

시약·촉매·용매 1

HCID 7583Diphenyl Ether용매

실험 절차

100 mL of diphenyl ether was heated to reflux followed by addition of 5.00 g (13.6 mmol) diethyl 2-((2-bromo-4-cyanophenylamino)methylene)malonate in portions in 30 minutes. The resulting brown solution was reflux for another hour and then cooled down to room temperature. The precipitate was collected and washed with hexanes (15 mL×3) to give 5.69 g of a light brown solid as the desired product. MS ESI (m/z) 321 (M+1)+.

후처리

  1. temperatureto reflux
  2. temperatureThe resulting brown solution was reflux for another hour
  3. customThe precipitate was collected
  4. washwashed with hexanes (15 mL×3)

출처 및 근거

ORD 기록
ord-8df4cd917c4c454cbf0df90f444050d8
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08697875B2

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