Sodium Chloride → HCID 67225376, 화합물

HRID 2367880

반응식

HRID 2367880 반응식
[CH3:1][N:2]([CH3:10])[N:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.[Cl-].[NH4+:12].[C-:13]#[N:14].[Na+].[Cl-].[Na+]>N>[NH2:12][C:6]1([C:13]#[N:14])[CH2:7][CH2:8][N:3]([N:2]([CH3:10])[CH3:1])[CH2:4][CH2:5]1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 25517Ammonium ChlorideHCID 567377821-(Dimethylamino)-4-piperidinone

생성물 1

HCID 67225376HCID 67225376, 화합물

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

6.3 g 1-Dimethylamino-piperidin-4-one (prepared as described in Journal of Medicinal & Pharmaceutical Chemistry, 4, 423-36; 1961) is dissolved in 135 ml aqueous ammonia (25%). To this solution 3.55 g ammonium chloride is added, then 4.34 g sodium cyanide. The reaction mixture is stirred at room temperature for 18 hours. Then the mixture is saturated with sodium chloride, and four times extracted with ethyl acetate. The organic layer is dried over sodium sulfate, and the solvent is evaporated, to yield 5.6 g 4-Amino-1-dimethylamino-piperidine-4-carbonitrile as a yellow oil. 1H-NMR (CDCl3): 2.95 ppm (m, 2H), 2.65 ppm (m, 2H), 2.40 ppm (s, 6H), 2.05 ppm (m, 2H), 1.80 ppm (m, 2H), 1.75 ppm (s, broad, 2H).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer is dried over sodium sulfate
  3. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-a2581c7f0c7e42fb9f16515d00b2bf06
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703165B2

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