Methylamine → HCID 67225397, 화합물

HRID 2367884

반응식

HRID 2367884 반응식
[CH3:1][N:2]([CH3:10])[N:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.Cl.[CH3:12][NH2:13].[CH3:14][NH2:15].[C-]#N.[K+]>O>[CH3:1][N:2]([CH3:10])[N:3]1[CH2:8][CH2:7][C:6]([NH:15][CH3:14])([C:12]#[N:13])[CH2:5][CH2:4]1

참가 물질

6

반응물 4

HCID 6329MethylamineHCID 9032Potassium CyanideHCID 6364545Methylamine hydrochlorideHCID 567377821-(Dimethylamino)-4-piperidinone

생성물 1

HCID 67225397HCID 67225397, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

5.5 g 1-Dimethylamino-piperidin-4-one (prepared as described in Journal of Medicinal & Pharmaceutical Chemistry, 4, 423-36; 1961), 4.2 g methylamine hydrochloride and 4.9 ml methylamine solution (40% in water) are mixed in 35 ml water, then to this mixture a solution of 4 g potassium cyanide in 10 ml water is added. The resulting mixture is stirred at room temperature for 3 days, then extracted with ethyl acetate, the organic layer dried over sodium sulfate, and the solvent evaporated. 5.3 g 1-Dimethylamino-4-methylamino-piperidine-4-carbonitrile is obtained. 1H-NMR (CDCl3): 2.86 ppm (m, 2H), 2.57 ppm (m, 2H), 2.44 ppm (s, 3H), 2.32 ppm (s, 6H), 2.00 ppm (m, 2H), 1.69 ppm (m, 2H).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialthe organic layer dried over sodium sulfate
  3. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-9cdbaf4bb1e74539b2d084de1c4c3ae6
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703165B2

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