Ammonia → 2-Phenyl-3-phenylamino-benzo(b)thiophene

HRID 236796

반응식

HRID 236796 반응식
[C:1]1([S:7][CH:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9](O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:18]>C1C=CC=CC=1>[C:12]1([C:8]2[S:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=3[C:9]=2[NH:18][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 2396052-Phenyl-2-(phenylsulfanyl)acetic acid

생성물 1

HCID 166403612-Phenyl-3-phenylamino-benzo(b)thiophene

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

3.0 g of anilide of phenylthio-phenyl acetic acid (colourless needles in a mixture of benzene and petroleum ether mp 142°-143°) in 130 g of polyphosphoric acid are heated to 100° for 19 hours. The cooled reaction mixture is poured onto water, made alkaline by concentrated ammonia and extracted with methylene chloride. By drying over sodium sulphate and evaporating the extracts of methylene chloride, 1.7 g (60.0% of theory) of yellow oil are obtained which are recrystallized in ethanol: 1.5 g (45% of theory) of yellow crystals, mp 150°-151° (ethanol).

후처리

  1. temperatureare heated to 100° for 19 hours
  2. customThe cooled reaction mixture
  3. additionis poured onto water
  4. extractionextracted with methylene chloride
  5. dry with materialBy drying over sodium sulphate
  6. customevaporating the extracts of methylene chloride, 1.7 g (60.0% of theory) of yellow oil
  7. customare obtained which
  8. customare recrystallized in ethanol

출처 및 근거

ORD 기록
ord-72aa0048b1f947589c78b839a1434659
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04157399

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