Hydrogen chloride-ethyl acetate → N-[(1S)-2-({1-[6-(2-cyclopropylethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl}oxy)-1-methylethyl]acetamide
반응식
[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[CH:33]=[CH:32][C:10]3[N:11]=[C:12]([N:14]4[CH2:19][CH2:18][CH:17]([O:20][CH2:21][C@@H:22]([NH:24][C:25](=O)[O:26]C(C)(C)C)[CH3:23])[CH2:16][CH2:15]4)[O:13][C:9]=3[CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:35](OCC)(=O)C>>[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[CH:33]=[CH:32][C:10]3[N:11]=[C:12]([N:14]4[CH2:19][CH2:18][CH:17]([O:20][CH2:21][C@@H:22]([NH:24][C:25](=[O:26])[CH3:35])[CH3:23])[CH2:16][CH2:15]4)[O:13][C:9]=3[CH:8]=2)[CH2:2][CH2:3]1참가 물질
3
실험 절차
To tert-butyl [(1S)-2-({1-[6-(2-cyclopropylethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl}oxy)-1-methylethyl]carbamate (5.84 g) was added 4M hydrogen chloride/ethyl acetate (50 mL), and the mixture was stirred at room temperature for 15 min, and concentrated. Pyridine (50 mL) and acetic anhydride (50 mL) were added to the residue, and the mixture was stirred at room temperature for 20 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (NH, ethyl acetate/hexane) and recrystallized from ethyl acetate/hexane to give the title compound (3.83 g) as white crystals.
후처리
- concentrationconcentrated
- additionPyridine (50 mL) and acetic anhydride (50 mL) were added to the residue
- stirringthe mixture was stirred at room temperature for 20 min
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe residue was purified by silica gel chromatography (NH, ethyl acetate/hexane)
- customrecrystallized from ethyl acetate/hexane
출처 및 근거
- ORD 기록
- ord-48d5c38400aa46f3bdfe275462484bd3
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08703758B2
반응 노트
불러오는 중…