HCID 57517503, 화합물 → 4-(Cyclopropylmethoxy)-3-fluorobenzenamine

HRID 2368123노트

반응식

HRID 2368123 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1>CO.[C].[Pd]>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=2[F:15])[CH2:2][CH2:3]1

참가 물질

4

반응물 1

HCID 57517503HCID 57517503, 화합물

생성물 1

HCID 196272444-(Cyclopropylmethoxy)-3-fluorobenzenamine수율 96.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A suspension of 1-(cyclopropylmethoxy)-2-fluoro-4-nitrobenzene (18.3 g) and 5% palladium carbon (containing water (50%), 1.84 g) in methanol (289 mL) was stirred for 3 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (15.2 g).

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2bc80886d5f54fa9af817617c089e82f
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703758B2

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