N,N,1-trimethyl-4-nitropyrazole-3-carboxamide → 4-Amino-N,N,1-trimethyl-1H-pyrazole-3-carboxamide
반응식
[CH3:1][N:2]([CH3:14])[C:3]([C:5]1[C:9]([N+:10]([O-])=O)=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]>C(O)C.[Pd]>[CH3:1][N:2]([CH3:14])[C:3]([C:5]1[C:9]([NH2:10])=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]참가 물질
4
실험 절차
A solution of 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid dimethylamide (100 mg, 0.5 mmol) in ethanol (4 ml) was flushed with argon and treated with Pd/C5% (40 mg, 0.02 mmol). The reaction vessel was evacuated and flushed with hydrogen three times and the reaction was stirred at ambient temperature overnight. The reaction mixture was filtrated and the solvent was evaporated to yield an off-white solid material (83 mg, 98%) which was used without further purification.
후처리
- customThe reaction vessel was evacuated
- customflushed with hydrogen three times
- filtrationThe reaction mixture was filtrated
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-a53c952c409a4df9aca132455590e2c5
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08703768B2
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