2-Methylpyrrolidine → HCID 178426211, 화합물
반응식
[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][NH:3]1.C[O:8][C:9]([C:11]1[C:15]([NH:16][C:17]([C:19]2[C:24]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[CH:23][CH:22]=[C:21]([CH:32]3[CH2:34][CH2:33]3)[N:20]=2)=[O:18])=[CH:14][N:13]([CH3:35])[N:12]=1)=O>>[CH:32]1([C:21]2[N:20]=[C:19]([C:17](=[N:16][C:15]3[C:11]([C:9]([N:3]4[CH2:4][CH2:5][CH2:6][CH:2]4[CH3:1])=[O:8])=[N:12][N:13]([CH3:35])[CH:14]=3)[OH:18])[C:24]([NH:25][C:26]3[CH:31]=[N:30][CH:29]=[N:28][CH:27]=3)=[CH:23][CH:22]=2)[CH2:34][CH2:33]1참가 물질
3
실험 절차
According to the general method described above (step 5), reaction of 2-methylpyrrolidine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (19%) as sticky yellow solid.
출처 및 근거
- ORD 기록
- ord-a61f937711ee472e843a604f434304c2
- 출처 데이터셋
- uspto-grants-2014_04