2-Methoxyethylamine → Ethyl 5-bromo-2-((2-methoxyethyl)amino)pyrimidine-4-carboxylate
반응식
[CH2:1]([O:3][C:4]([C:6]1[C:11]([Br:12])=[CH:10][N:9]=[C:8](S(C)(=O)=O)[N:7]=1)=[O:5])[CH3:2].[CH3:17][O:18][CH2:19][CH2:20][NH2:21]>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[C:11]([Br:12])=[CH:10][N:9]=[C:8]([NH:21][CH2:20][CH2:19][O:18][CH3:17])[N:7]=1)=[O:5])[CH3:2]참가 물질
4
반응 조건
- 온도
- 45 °C
실험 절차
A solution of 5-bromo-2-methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester (86 mg, 0.27 mmol) in dichloromethane (2 ml) was treated with 2-methoxyethylamine (124 μl, 1.44 mmol) under argon atmosphere and heated to 45° C. for 2 h. All volatiles were removed and the product was obtained after purification by silica gel chromatography using a heptane/ethyl acetate gradient as colorless oil (72 mg, 82%).
후처리
- customAll volatiles were removed
- customthe product was obtained
- customafter purification by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-945e0384a15d44f2ab0e66508d026427
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08703768B2
반응 노트
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