Metaperiodic acid → 3-Chloro-4-cyclohexylbenzaldehyde

HRID 236834

반응식

HRID 236834 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([OH:17])CO)[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.I(O)(=O)(=O)=O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)[CH:14]=[O:17]

참가 물질

5

반응물 2

HCID 65185Metaperiodic acidHCID 129398511-(3-Chloro-4-cyclohexylphenyl)ethane-1,2-diol

생성물 1

HCID 107277773-Chloro-4-cyclohexylbenzaldehyde

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To 115 g. of 1-(3-chloro-4-cyclohexylphenyl)-1,2-ethanediol in tetrahydrofuran (800 ml.) is added a solution of periodic acid (102 g.) in ether (750 ml.). The reaction mixture is stirred under nitrogen overnight. The reaction mixture is filtered and the filtrate is washed with water (3×200 ml) and placed over sodium sulfate. Removal of solvent gives a liquid residue which is then distilled to give 3-chloro-4-cyclohexylbenzaldehyde.

후처리

  1. filtrationThe reaction mixture is filtered
  2. washthe filtrate is washed with water (3×200 ml)
  3. customRemoval of solvent
  4. customgives a liquid residue which
  5. distillationis then distilled

출처 및 근거

ORD 기록
ord-458233f12a5d40beb062c3c79822573b
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04157449

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