돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2368364생성일: 2026년 10월 27일

6-Cyclopropyl-3-(pyridin-3-ylamino)pyrazine-2-carboxylic acid → 6-Cyclopropyl-3-(pyridin-3-ylamino)-pyrazine-2-carboxylic acid [5-(azetidine-1-carbonyl)-1-methyl-1H-pyrazol-4-yl]-amide

https://huagongshe.com/reaction/2368364

반응식

참여 물질

역할이름HCID투입량
반응물6-Cyclopropyl-3-(pyridin-3-ylamino)pyrazine-2-carboxylic acidHCID 70096538—
반응물(4-Amino-2-methyl-2H-pyrazol-3-yl)-azetidin-1-yl-methanoneHCID 70098437—
생성물6-Cyclopropyl-3-(pyridin-3-ylamino)-pyrazine-2-carboxylic acid [5-(azetidine-1-carbonyl)-1-methyl-1H-pyrazol-4-yl]-amideHCID 58548168—

반응 단계

The product was obtained starting from 6-cyclopropyl-3-(pyridin-3-ylamino)pyrazine-2-carboxylic acid (30 mg, 0.12 mmol; example 217, step 2) and (4-amino-2-methyl-2H-pyrazol-3-yl)-azetidin-1-yl-methanone (27 mg, 0.15 mmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as light yellow solid (37 mg, 75%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08703768B2
출처 데이터셋uspto-grants-2014_04
ORD IDord-951730cb24314134811a636508b0fcef
출처 메모uspto-grants-2014_04