1-(2,3,6-Trifluorophenyl)ethanone → 2-(2,3,6-Trifluorophenyl)propan-2-ol
반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10](=[O:12])[CH3:11].[CH3:13][Mg]Br>C1COCC1>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10]([OH:12])([CH3:13])[CH3:11]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 1-(2,3,6-trifluorophenyl)ethanone (1.74 g, 10 mmol) in THF (10 mL) was added methyl magnesium bromide (7 mL, 21 mmol) at 0° C. The mixture was stirred at 0° C. for 1 hour. The reaction was quenched by addition of saturated aqueous ammonium chloride and was then extracted with EtOAc. The combined organic layers were washed with water, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel to afford 2-(2,3,6-trifluorophenyl)propan-2-ol. (74).
후처리
- customThe reaction was quenched by addition of saturated aqueous ammonium chloride
- extractionwas then extracted with EtOAc
- washThe combined organic layers were washed with water
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe residue was purified by flash column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-d05d134221fc4417be845ad4eeb67297
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08703776B2
반응 노트
불러오는 중…