Water → 6-Amino-5-nitroso-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

HRID 2368545노트

반응식

HRID 2368545 반응식
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6](=[S:13])[NH:5][C:4](=[O:14])[CH:3]=1.[N:15]([O-])=[O:16].[Na+].O>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6](=[S:13])[NH:5][C:4](=[O:14])[C:3]=1[N:15]=[O:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 576001846-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

생성물 1

HCID 576001906-Amino-5-nitroso-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
75 °C

실험 절차

6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (8.0 g, 0.038 mol) was mixed with sodium nitrite (3.1 g, 0.045 mol) in acetic acid (120 mL). The mixture was stirred at 75° C. for 1 h. The color of the reaction mixture became pink and then purple. The solution was allowed to cool down to room temperature, and water (40 mL) was added. The solid was collected by suction filtration and washed with water (50 mL) to produce the desired product, which was used directly for next step without further purification. LCMS calculated for C9H15N4O2S: (M+H) 243.1. Found 243.1.

후처리

  1. temperatureto cool down to room temperature
  2. filtrationThe solid was collected by suction filtration
  3. washwashed with water (50 mL)

출처 및 근거

ORD 기록
ord-3f70140d979b442c9f1daaa3e5cc3819
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703783B2

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