Morpholine → 7-Bromo-3-(3-morpholin-4-yl-3-oxopropyl)-9-pentyl-6,9-dihydro-5h-[1,2,4]triazolo[4,3-a]purin-5-one

HRID 2368595노트

반응식

HRID 2368595 반응식
[Br:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]3[C:12]([CH2:15][CH2:16][C:17](O)=[O:18])=[N:13][N:14]=[C:6]3[N:5]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:4]=2[N:3]=1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.C(N(CC)CC)C.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>C(Cl)Cl>[Br:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]3[C:12]([CH2:15][CH2:16][C:17]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[O:18])=[N:13][N:14]=[C:6]3[N:5]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:4]=2[N:3]=1

참가 물질

6

반응물 4

HCID 8083MorpholineHCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 250596563-(7-Bromo-5-oxo-9-pentyl-6,9-dihydro-5h-[1,2,4]triazolo[4,3-a]purin-3-yl)propanoic acid

생성물 1

HCID 250599157-Bromo-3-(3-morpholin-4-yl-3-oxopropyl)-9-pentyl-6,9-dihydro-5h-[1,2,4]triazolo[4,3-a]purin-5-one수율 63.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The mixture of 3-(7-bromo-5-oxo-9-pentyl-6,9-dihydro-5H[1,2,4]triazolo[4,3-a]purin-3-yl]propanoic acid (50 mg, 0.126 mmol), morpholine (21.0 mg, 0.252 mmol), triethylamine (25.5 mg, 0.252 mmol) and BOP (61.5 mg, 0.139 mmol) in CH2Cl2 (10 ml) was stirred at room temperature for 2 hours. After evaporation of solvent, the residue was purified by preparative LC-MS to afford the desired product (37.2 mg, 60%) as white solid. LCMS calculated for C18H25BrN7O3 (M+H): 466.1. Found: 466.1.

후처리

  1. customAfter evaporation of solvent
  2. customthe residue was purified by preparative LC-MS

출처 및 근거

ORD 기록
ord-9cc5eeb1ada847f9a9cdefb049687b97
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703783B2

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