Hydrazine → HCID 43840406, 화합물

HRID 2368704노트

반응식

Cl[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[C:5]([CH3:14])[CH:6]=[CH:7][C:8]=2[CH3:13])[N:3]=1.[NH2:15][NH2:16]>>[NH:15]([C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[C:5]([CH3:14])[CH:6]=[CH:7][C:8]=2[CH3:13])[N:3]=1)[NH2:16]

참가 물질

반응물 2

HCID 9321Hydrazine

HCID 269162HCID 269162, 화합물

생성물 1

HCID 43840406HCID 43840406, 화합물수율 38%

실험 절차

A solution of 2-chloro-4,5,8-trimethylquinoline (2.2 g, 10.7 mmoles) in NH2NH2 was reacted as outlined in Scheme 1 above to give the desired title compound (830 mg, 38%). Spectroscopic data: 1H NMR (300 MHz, CDCl3) δ ppm 2.62 (s, 3 H) 2.78 (s, 6 H) 4.13 (br. s., 2 H) 5.74 (br. s., 1 H) 6.52 (s, 1 H) 6.95 (d, J=7.03 Hz, 1 H) 7.28 (d, 1 H).

출처 및 근거

ORD 기록: ord-4d5f059c2228461281d6e92c8275b3f1
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08703797B2

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