Thionyl Chloride → HCID 67456441, 화합물

HRID 2368765

반응식

HRID 2368765 반응식
O[CH:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.S(Cl)([Cl:15])=O>C(Cl)Cl>[Cl:15][CH:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 145153231-hydroxy-2,3-dihydro-1H-indene-5-carbonitrile

생성물 1

HCID 67456441HCID 67456441, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-Hydroxy-2,3-dihydro-1H-indene-5-carbonitrile (4.77 g, 30 mmol) was dissolved in 10 mL of methylene dichloride. While cooled on ice, thionyl chloride (6.6 ml, 90 mmol) was added dropwise within about 15 minutes. The solution was concentrated after being stirred for 3 hours. The residue was dissolved in ethyl acetate and the solution obtained was washed with cooled brine for 3 times, dried over anhydrous magnesium sulfate, and concentrated to obtain 1-chloro-2,3-dihydro-1H-indene-5-carbonitrile.

후처리

  1. additionwas added dropwise within about 15 minutes
  2. concentrationThe solution was concentrated
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. customthe solution obtained
  5. washwas washed with cooled brine for 3 times
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1bceab36026f4f35a34eaa2018214aca
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703771B2

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