(2E)-3-(Dimethylamino)-1-(4-Pyridinyl)-2-Propen-1-One → Imatinib Impurity 38

반응식

CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][C:20]=1[NH:28][C:29]([NH2:31])=[NH:30]>>[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][C:20]=1[NH:28][C:29]1[N:31]=[C:5]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[CH:4]=[CH:3][N:30]=1

참가 물질

반응물 2

HCID 5396716(2E)-3-(Dimethylamino)-1-(4-Pyridinyl)-2-Propen-1-One

HCID 178426711HCID 178426711, 화합물

생성물 1

HCID 58579018Imatinib Impurity 38

실험 절차

The title compound was prepared by condensation reaction between (2E)-3-(dimethylamino)-1-pyridin-4-ylprop-2-en-1-one and N-(2-methyl-5-nitrophenyl)guanidine nitrate, according to the procedure described in Step C of EXAMPLE 8. MS (M+1)=308.11.

출처 및 근거

ORD 기록: ord-91220e99f455473f8c17c74ee0d33828
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08703771B2

반응 노트

불러오는 중…