Bromine → N-[4-(2-Bromoacetyl)Phenyl]Acetamide
반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH3:13])=[O:12])=[CH:6][CH:5]=1)=[O:3].[Br:14]Br>O1CCOCC1.C(OCC)C>[Br:14][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:12])[CH3:13])=[CH:6][CH:5]=1)=[O:3]참가 물질
4
실험 절차
To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).
후처리
- filtrationThe solid was collected by filtration
- washwashed with diethyl ether
- customdried under high vacuum
출처 및 근거
- ORD 기록
- ord-43e73a7d6a6541cb8fbdd66d015a07f5
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06852731B2
반응 노트
불러오는 중…