Bromine → N-[4-(2-Bromoacetyl)Phenyl]Acetamide

HRID 23692

반응식

HRID 23692 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH3:13])=[O:12])=[CH:6][CH:5]=1)=[O:3].[Br:14]Br>O1CCOCC1.C(OCC)C>[Br:14][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:12])[CH3:13])=[CH:6][CH:5]=1)=[O:3]

참가 물질

4

반응물 2

HCID 24408BromineHCID 75937N-(p-acetylphenyl)acetamide

생성물 1

HCID 12364739N-[4-(2-Bromoacetyl)Phenyl]Acetamide수율 62.5%

시약·촉매·용매 1

HCID 23504442p-Dioxane ethyl ether용매

실험 절차

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

후처리

  1. filtrationThe solid was collected by filtration
  2. washwashed with diethyl ether
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-43e73a7d6a6541cb8fbdd66d015a07f5
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852731B2

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