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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Water → 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-6-methoxy-4-(piperidin-1-yl)pyridine-3,5-dicarbonitrile

HRID 2369213
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HRID 2369213 반응식
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:5]([C:16]#[N:17])=[C:4]([S:18][CH2:19][C:20]2[N:21]=[C:22]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[S:23][CH:24]=2)[N:3]=1.[CH3:32][O-:33].[Na+].O>CO>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([C:22]2[S:23][CH:24]=[C:20]([CH2:19][S:18][C:4]3[C:5]([C:16]#[N:17])=[C:6]([N:10]4[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]4)[C:7]([C:8]#[N:9])=[C:2]([O:33][CH3:32])[N:3]=3)[N:21]=2)=[CH:26][CH:27]=1
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참가 물질

5

반응물 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 866400092-Chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-piperidin-1-ylpyridine-3,5-dicarbonitrile

생성물 1

HCID 685525762-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-6-methoxy-4-(piperidin-1-yl)pyridine-3,5-dicarbonitrile

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

100.0 mg (0.21 mmol) of the compound from Example 4A are initially charged in 2 ml of dry methanol. 12.2 mg (0.23 mmol) of sodium methoxide are added to this solution, and the mixture is stirred at +65° C. for 20 h. After cooling to RT the reaction mixture is stirred into 2 ml of water and stirred at RT for 1 h. The precipitate that is formed is filtered off with suction and washed with 1 ml of cold water. Purification is carried out by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

후처리

  1. stirringstirred at RT for 1 h
  2. customThe precipitate that is formed
  3. filtrationis filtered off with suction
  4. washwashed with 1 ml of cold water
  5. customPurification

출처 및 근거

ORD 기록
ord-27b8c2da34f44f10b06b5cddc2ae0367
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08703934B2

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