Methylamine → 2-((Methylamino)methyl)fluorene

HRID 2369472

반응식

HRID 2369472 반응식
C1C2CC3C(=CC=CC=3)C=2C=CC=1C(Cl)=O.CN.[CH3:19][NH:20][C:21]([C:23]1[CH:35]=[CH:34][C:33]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:26][C:25]=2[CH:24]=1)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1.CCOCC>[CH3:19][NH:20][CH2:21][C:23]1[CH:35]=[CH:34][C:33]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:26][C:25]=2[CH:24]=1

참가 물질

7

반응물 4

HCID 6329MethylamineHCID 10704314N-methyl fluorene-2-carboxamideHCID 178156299H-Fluorene-2-carbonyl chlorideHCID 21226445Aluminium lithium hydride

생성물 1

HCID 126897512-((Methylamino)methyl)fluorene

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of fluorene-2-carbonyl chloride (prepared from fluorene-2-carboxylic acid and oxalyl chloride) in THF is added to aqueous methylamine (2 molar equivalents) to prepare N-methyl fluorene-2-carboxamide. Reduction of the amide using LiAlH4 in ether provides 2-((methylamino)methyl)fluorene. The amine is protected by reaction with di-tert-butyl dicarbonate to provide 2-((N-tBOC—N-methylamino)methyl)fluorene.

출처 및 근거

ORD 기록
ord-c73659778c2e4efd86e08a62815c9238
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703907B2

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