3-Methylcinnamic acid → 3-(3-Methylcyclohexyl)propanoic acid

HRID 2369771노트

반응식

HRID 2369771 반응식
[CH3:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1>C(O)(=O)C>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:3]1

참가 물질

3

반응물 1

HCID 20634483-Methylcinnamic acid

생성물 1

HCID 574294053-(3-Methylcyclohexyl)propanoic acid수율 95%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
150 °C

실험 절차

5% Ru/Al2O3 (3 g, 5 wt %), (2E)-3-(3-methylphenyl)acrylic acid (60 g, 0.37 mol) and acetic acid (300 mL) were charged into a 500 mL autoclave vessel. The mixture was vigorously stirred under a hydrogen atmosphere (40 bar) at 150° C., for 3 days. The catalyst was filtered and the product was dissolved in ethyl acetate (500 mL), washed with water (500 mL) and brine (500 mL). The organic phase was dried over sodium sulphate, filtered and evaporated to yield crude 3-(3-methylcyclohexyl)propanoic acid (60 g, 0.35 mol, 95% yield) as a colourless oil.

후처리

  1. filtrationThe catalyst was filtered
  2. dissolutionthe product was dissolved in ethyl acetate (500 mL)
  3. washwashed with water (500 mL) and brine (500 mL)
  4. dry with materialThe organic phase was dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-395ffb6596814234a4e9633ecfd3b857
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08709994B2

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