1-Phenethylamine, (-)- → HCID 178462014, 화합물

HRID 2369961노트

반응식

HRID 2369961 반응식
FC1C=CC=C(F)C=1O[C:5]1[O:6][C:7]([CH3:16])([CH3:15])[C:8]([CH3:14])([CH3:13])[S:9](=[O:12])(=[O:11])[N:10]=1.[C:22]1([C@@H:28]([NH2:30])[CH3:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([C@@H:28]([NH:30][C:5]2[O:6][C:7]([CH3:15])([CH3:16])[C:8]([CH3:13])([CH3:14])[S:9](=[O:11])(=[O:12])[N:10]=2)[CH3:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

3

반응물 2

HCID 758181-Phenethylamine, (-)-HCID 867054542-(2,6-Difluorophenoxy)-5,5,6,6-tetramethyl-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide

생성물 1

HCID 178462014HCID 178462014, 화합물수율 50.9%

실험 절차

A mixture of 194 mg of 2-(2,6-difluorophenoxy)-5,5,6,6-tetramethyl-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide and 737 mg of (S)-1-phenylethylamine was stirred at room temperature for 16 hours and then purified in a purification laboratory by means of preparative HPLC. The combined product-containing fractions were alkalized with 25% aqueous ammonia solution and extracted three times with 30 ml of ethyl acetate, and the combined organic phases were dried over MgSO4 and concentrated by rotary evaporation. This gave the product (96 mg) with a molecular weight of 310.4 g/mol (C15H22N2O3S); MS (ESI): m/e=311 (M+H+).

후처리

  1. custompurified in a purification laboratory by means of preparative HPLC
  2. additionThe combined product-containing fractions
  3. extractionextracted three times with 30 ml of ethyl acetate
  4. dry with materialthe combined organic phases were dried over MgSO4
  5. concentrationconcentrated by rotary evaporation

출처 및 근거

ORD 기록
ord-cc75699783da45c9935f191b8d71f8ad
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08710050B2

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