Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 1-(3-Chlorophenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 1-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine | HCID 1019725 | — |
| 촉매 | titanium(III) trichloride | HCID 10313229 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
반응 단계
1-[(p-Nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine is reduced with aqueous titanium trichloride in ether solution by dropwise addition of aqueous TiCl3 until the purple color is no longer discharged. The reaction progress is followed by thin layer chromatography. Work-up with concentrated ammonium hydroxide and subsequently aqueous potassium hydroxide followed by isolation, drying, and concentration of the organic layer gives 1-[p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04159331 |
| 출처 데이터셋 | uspto-grants-1979_06 |
| ORD ID | ord-abb38bd69cbe41e4b74d1fd6d4d564b2 |
| 출처 메모 | uspto-grants-1979_06 |