Benzoyl Peroxide → NCS Chloride
반응식
FC1C=CC=C(C)N=1.[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C1C=CC=CC=1>[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.[Cl-:16]참가 물질
5
실험 절차
2-Fluoro-6-methylpyridine (1.11 g, 10 mmol), NCS (2.0 g, 15 mmol), and catalytic benzoyl peroxide were dissolved in benzene and heated to reflux overnight. The reaction was concentrated and diluted with water and EtOAc. The organic layer was washed with saturated aq. NaHCO3, dried, filtered, and concentrated. The residue was purified on silica gel to give the desired product.
후처리
- temperatureheated
- temperatureto reflux overnight
- concentrationThe reaction was concentrated
- additiondiluted with water and EtOAc
- washThe organic layer was washed with saturated aq. NaHCO3
- customdried
- filtrationfiltered
- concentrationconcentrated
- customThe residue was purified on silica gel
출처 및 근거
- ORD 기록
- ord-d26674f059d34805801ad1ef938025ed
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08710081B2
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