2-Chloro-4,6-dimethylpyrimidine → 1-[(4,6-Dimethyl-2-pyrimidinyl)]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]piperazine

HRID 237046

반응식

HRID 237046 반응식
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[Cl:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([S:28]([N:31]4[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]4)(=[O:30])=[O:29])=[CH:24][CH:23]=3)=[CH:16][CH:17]=[N:18]2)=[CH:13][CH:12]=1>>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([N:34]2[CH2:35][CH2:36][N:31]([S:28]([C:25]3[CH:26]=[CH:27][C:22]([NH:21][C:15]4[C:14]5[C:19](=[CH:20][C:11]([Cl:10])=[CH:12][CH:13]=5)[N:18]=[CH:17][CH:16]=4)=[CH:23][CH:24]=3)(=[O:29])=[O:30])[CH2:32][CH2:33]2)[N:3]=1

참가 물질

3

반응물 2

HCID 205502-Chloro-4,6-dimethylpyrimidineHCID 54297387[[4-[(7-Chloro-4-quinolinyl)amino]phenyl]sulfonyl]piperazine

생성물 1

HCID 213149341-[(4,6-Dimethyl-2-pyrimidinyl)]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]piperazine

실험 절차

In the manner given in Example 9, part E, 2-chloro-4,6-dimethylpyrimidine is heated with [[4-[(7-chloro-4-quinolinyl)amino]phenyl]sulfonyl]piperazine to give 1-[(4,6-dimethyl-2-pyrimidinyl)]-4-[[4-[[7-chloro-4-quinolinyl]amino]phenyl]sulfonyl]piperazine.

출처 및 근거

ORD 기록
ord-a4e7b78715994fb29acec40919aa7af3
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159331

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