Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide → 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide | HCID 57725414 | — |
| 반응물 | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamine | HCID 57725501 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide | HCID 57725579 | — |
반응 단계
To a solution of 1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-ethylamine (3 eq) in THF was added 4-(2-methanesulfinyl-benzooxazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (1 eq). This was stirred at room temperature for 8 hours, concentrated and the residue was purified by preparatory reverse phase HPLC. MH+=447.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08710048B2 |
| 출처 데이터셋 | uspto-grants-2014_04 |
| ORD ID | ord-e97f334a6cfa450b8285ab30fdd4d2f4 |
| 출처 메모 | uspto-grants-2014_04 |