Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2370514생성일: 2026년 10월 26일
Cyclohexanemethylamine → 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide
https://huagongshe.com/reaction/2370514
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclohexanemethylamine | HCID 76688 | — |
| 반응물 | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 57725483 | — |
반응 단계
To the solution of 4-(2-methanesulfinyl-benzothiazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (25 mg, 0.072 mmol, 1.0 eq) in DMF (5004), was added cyclohexylmethylamine (18.7 μL, 0.144 mmol, 2.0 eq) and reaction was stirred at 70° C. overnight. The neat reaction mixture was purified on reverse phase preparatory HPLC. Pure fractions were lyophilized as TFA salts. M+H=397.1
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08710048B2 |
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| 출처 데이터셋 | uspto-grants-2014_04 |
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| ORD ID | ord-3c7e625c067a42bea22b0e1afec5afed |
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| 출처 메모 | uspto-grants-2014_04 |
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