Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2370534생성일: 2026년 10월 24일
Diisopropylethylamine → (S)-tert-butyl 3-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate
https://huagongshe.com/ko/reaction/2370534
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | tert-butyl (3S)-3-aminopiperidine-1-carboxylate | HCID 1501975 | — |
| 반응물 | 6-(2-Chloropyridin-4-yloxy)-2-(methylsulfinyl)benzo[d]thiazole | HCID 57725430 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | (S)-tert-butyl 3-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate | HCID 57725807 | 112% |
반응 단계
To the solution of 6-(2-chloropyridin-4-yloxy)-2-(methylsulfinyl)benzo[d]thiazole (100 mg, 0.31 mmol) in 1.6 ml of NMP was added (S)-tert-butyl 3-aminopiperidine-1-carboxylate (200 mg, 1 mmol) and DIPEA (70 μL, 0.4 mmol). The reaction solution was stirred at 95° C. for 5 days. The crude reaction solution was purified on prep HPLC and evaporated in vaccuo to give (S)-tert-butyl 3-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate (160 mg) as TFA salt. ES/MS m/z 461.1 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08710048B2 |
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| 출처 데이터셋 | uspto-grants-2014_04 |
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| ORD ID | ord-54e39376a176469aa5db12fd22dbd2de |
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| 출처 메모 | uspto-grants-2014_04 |
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