Potassium Carbonate → HCID 86618569, 화합물
반응식
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][C:12]3C=CN=[C:14]([C:18]([NH:20][CH3:21])=O)[CH:13]=3)[CH:8]=[C:7]([CH3:22])[C:5]=2[N:6]=1.Br[CH2:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1.[C:31](=O)([O-])[O-].[K+].[K+].C[N:38]1[C:42](=[O:43])CCC1>>[CH:25]1([CH2:24][NH:1][C:2]2[S:3][C:4]3[CH:10]=[C:9]([O:11][CH2:12][C:13]4[CH:14]=[CH:18][N:20]=[C:21]([C:42]([NH2:38])=[O:43])[CH:31]=4)[CH:8]=[C:7]([CH3:22])[C:5]=3[N:6]=2)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1참가 물질
5
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- 온도
- 80 °C
실험 절차
To the solution of 4-(2-amino-4-methylbenzo[d]thiazol-6-yloxy)-N-methylpicolinamide (30 mg, 0.095 mmol, 1.0 eq) in 1 mL of NMP was added bromomethyl cyclohexane (20 μL, 0.142 mmol, 1.5 eq) and potassium carbonate (40 mg, 0.285 mmol, 3.0 eq) at room temperature. The reaction mixture was stirred at 80° C. for 12 hours and thereafter purified via reverse phase HPLC. LC/MS (m/z) [411.1] (MH+)