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[F:1][CH:2](F)[CH2:3]I.[CH3:6][C:7]1([CH3:18])[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH2:10][NH:9][CH2:8]1.BrCCF.C([O-])([O-])=O.[K+].[K+]>>[F:1][CH2:2][CH2:3][N:9]1[CH2:8][C:7]([CH3:6])([CH3:18])[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH2:10]1참가 물질
5
실험 절차
The title compound was prepared as described in Example 224B, substituting Example 224A and 1,1-difluoro-2-iodoethane with 4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine and 1-bromo-2-fluoroethane, respectively, and using 2.5 equivalent of K2CO3.
출처 및 근거
- ORD 기록
- ord-3739f900508f44468c459c910bdbdc5d
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08710065B2
연결된 노트
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