4-Fluoro-3-methoxybenzaldehyde → 6-Fluoro-7-methoxyisoquinoline

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH:6]=O.FC1C=C2C(=CC=1)C=[N:18][CH:17]=[CH:16]2>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:8]([CH:16]=[CH:17][N:18]=[CH:6]2)=[CH:9][C:10]=1[F:11]

참가 물질

반응물 2

HCID 27373584-Fluoro-3-methoxybenzaldehyde

HCID 218898476-Fluoroisoquinoline

생성물 1

HCID 592685356-Fluoro-7-methoxyisoquinoline

실험 절차

Starting from 3-methoxy-4-fluoro-benzaldehyde, the title compound was prepared by the same reaction sequence as 6-fluoro-isoquinoline (5). Rt=0.70 min (Method #4). Detected mass: 178.1 (M+H+).

출처 및 근거

ORD 기록: ord-97b713cbcf8d424ca28da481a84164f6
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08710228B2

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