Isoquinoline, 5-chloro-6-fluoro- → HCID 178454059, 화합물

반응식

[Cl:1][C:2]1[C:11](F)=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[C:13]([O:17][C:18](=[O:27])[NH:19][C@H:20]1[CH2:25][CH2:24][C@@H:23]([OH:26])[CH2:22][CH2:21]1)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18](=[O:27])[NH:19][C@H:20]1[CH2:21][CH2:22][C@@H:23]([O:26][C:11]2[C:2]([Cl:1])=[C:3]3[C:8](=[CH:9][CH:10]=2)[CH:7]=[N:6][CH:5]=[CH:4]3)[CH2:24][CH2:25]1)([CH3:16])([CH3:14])[CH3:15]

참가 물질

반응물 2

HCID 59818261Isoquinoline, 5-chloro-6-fluoro-

HCID 178418813HCID 178418813, 화합물

생성물 1

HCID 178454059HCID 178454059, 화합물

실험 절차

Starting from 5-chloro-6-fluoro-isoquinoline (8) and cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester the title compound was prepared by the method described for trans-[4-(5-chloro-isoquinolin-6-yloxy)-cyclohexyl]carbamic acid tert-butyl ester (10), whereas DMF was used as solvent. Rt=1.14 min (Method #4). Detected mass: 377.2/379.2 (M+H+).

출처 및 근거

ORD 기록: ord-a3f0ff841f2a423495e14983eb2a88e8
출처 데이터셋: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08710228B2

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