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[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[CH2:4][NH:3]1.Cl.[F:15][C:16]([F:36])([F:35])[C:17]1[CH:22]=[CH:21][C:20]([C@@H:23]([C:25]2[C:30]([C:31]([F:34])([F:33])[F:32])=[CH:29][CH:28]=[CH:27][N:26]=2)[NH2:24])=[CH:19][CH:18]=1>>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:24][C@@H:23]([C:20]3[CH:21]=[CH:22][C:17]([C:16]([F:36])([F:15])[F:35])=[CH:18][CH:19]=3)[C:25]3[C:30]([C:31]([F:32])([F:33])[F:34])=[CH:29][CH:28]=[CH:27][N:26]=3)=[O:13])=[CH:8][CH:9]=2)[CH2:4][NH:3]1참가 물질
3
실험 절차
1-Oxoisoindoline-5-carboxylic acid was then coupled with Intermediate 1 using the general methods described above for the amide coupling reaction (Table 2) to provide the title compound, (S)-1-oxo-N-((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)isoindoline-5-carboxamide, as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 8.92 (d, J=4.7 Hz, 1H), 8.36 (d, J=7.4 Hz, 1H), 8.09-7.99 (m, 2H), 7.97-7.88 (m, 2H), 7.65-7.53 (m, 5H), 7.51 (dd, J=4.9, 7.8 Hz, 1H), 6.90 (d, J=7.6 Hz, 1H), 4.54 (s, 2H). MS (ESI pos. ion) m/z: 480.2 (M+H).
출처 및 근거
- ORD 기록
- ord-309d6dcc52424f45a90be9177b87ec7b
- 출처 데이터셋
- uspto-grants-2014_04
- 특허 번호
- US08710043B2
연결된 노트
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