5-(o-Fluorophenyl)-3-hydrazino-1,2,4-triazine → 7-(o-Fluorophenyl)-3-methyl-1,2,4-triazolo[4,3-b]-1,2,4-triazine

HRID 237093노트

반응식

HRID 237093 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]([NH:14][NH2:15])[N:11]=[N:12][CH:13]=1.[C:16]([O-])([O-])(OCC)[CH3:17]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[N:12][N:11]2[C:16]([CH3:17])=[N:15][N:14]=[C:10]2[N:9]=1

참가 물질

3

반응물 2

HCID 125812735-(o-Fluorophenyl)-3-hydrazino-1,2,4-triazineHCID 86598186Ethyl ortho-acetate

생성물 1

HCID 125812757-(o-Fluorophenyl)-3-methyl-1,2,4-triazolo[4,3-b]-1,2,4-triazine

실험 절차

A mixture of 6.15 g. of 5-(o-fluorophenyl)-3-hydrazino-1,2,4-triazine and 50 ml. of ethyl orthoacetate is refluxed for 2.5 hours, cooled and the solid is collected by filtration and washed with hexane and ethanol, giving the desired product as yellow crystals, m.p. 227°-229° C.

후처리

  1. additionA mixture of 6.15 g
  2. temperaturecooled
  3. filtrationthe solid is collected by filtration
  4. washwashed with hexane and ethanol

출처 및 근거

ORD 기록
ord-8993d7c1ae9a4ce490a33fcb8a92ee1c
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159375

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