Thioacetamide → 2-Methyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one

HRID 2371047노트

반응식

HRID 2371047 반응식
[C:1](=[S:4])([NH2:3])[CH3:2].Br[CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][CH2:8][C:7]1=O>C(O)C>[CH3:2][C:1]1[S:4][C:10]2[C:11](=[O:12])[CH2:6][CH2:7][CH2:8][C:9]=2[N:3]=1

참가 물질

4

반응물 2

HCID 2723949ThioacetamideHCID 27704762-Bromocyclohexane-1,3-dione

생성물 1

HCID 149133692-Methyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethanethioamide (0.75 g, 10 mmol) in ethanol (20 mL) at room temperature was added 2-bromocyclohexane-1,3-dione (1.9 g, 10 mmol) in portions. The reaction solution was refluxed for 2 hours while stirring. After removal of solvents, the residue was diluted with water and washed with diethyl ether. The separated aqueous layer was basified with sodium carbonate solution. The resulting solid was collected by vacuum filtration, rinsed with water. The solid was suspended in methanol and followed by evaporation to dryness to produce the title compound.

후처리

  1. temperatureThe reaction solution was refluxed for 2 hours
  2. customAfter removal of solvents
  3. additionthe residue was diluted with water
  4. washwashed with diethyl ether
  5. filtrationThe resulting solid was collected by vacuum filtration
  6. washrinsed with water
  7. customfollowed by evaporation to dryness

출처 및 근거

ORD 기록
ord-ce6dc72c650a4d18bcf495da9bdd852e
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08710245B2

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