Trifluoroacetic acid → Ethyl 6-ethyl-3,4-dihydro-5-hydroxy-4-oxothieno[2,3-d]PYRIMIDINE-2-CARBOXYLATE

HRID 237123

반응식

HRID 237123 반응식
N[C:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[N:6][C:5]=2[S:4][C:3]=1[CH2:17][CH3:18].FC(F)(F)C([O-])=[O:22].[K+].FC(F)(F)C(O)=O>>[CH2:17]([C:3]1[S:4][C:5]2[N:6]=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][C:9](=[O:11])[C:10]=2[C:2]=1[OH:22])[CH3:18]

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 12516925Ethyl 5-amino-6-ethyl-3,4-dihydro-4-oxothieno[2,3-d]PYRIMIDINE-2-CARBOXYLATEHCID 23662811Potassium trifluoroacetate

생성물 1

HCID 23330393Ethyl 6-ethyl-3,4-dihydro-5-hydroxy-4-oxothieno[2,3-d]PYRIMIDINE-2-CARBOXYLATE

반응 조건

온도
25 °C

실험 절차

The diazonium fluoborate salt is prepared as in Procedure 63 from the amino compound produced in Procedure 51 yielding 0.03 mole of the required diazonium fluoborate. The latter is added in one portion to a solution of 0.03 mole of potassium trifluoroacetate in 13 ml. of trifluoroacetic acid at 0° C. The mixture is stirred at 25° C. for one hour and then refluxed overnight. The trifluoroacetic acid is evaporated in vacuo to give a residue which is triturated with water and filtered to give the desired product.

후처리

  1. customat 0° C
  2. temperaturerefluxed overnight
  3. customThe trifluoroacetic acid is evaporated in vacuo
  4. customto give a residue which
  5. customis triturated with water
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-b5eceba6e9d445f4bc3d61216a917bed
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159377

연결된 노트

불러오는 중…