Methanol → HCID 86745510, 화합물

HRID 2371420노트

반응식

HRID 2371420 반응식
[O:1]=[C:2]1[CH:7]([CH2:8][C:9]([OH:11])=[O:10])[S:6](=[O:13])(=[O:12])[C:5]2[S:14][C:15]([S:17](=[O:20])(=[O:19])[NH2:18])=[CH:16][C:4]=2[NH:3]1.S(=O)(=O)(O)O.[CH3:26]O>>[O:1]=[C:2]1[CH:7]([CH2:8][C:9]([O:11][CH3:26])=[O:10])[S:6](=[O:13])(=[O:12])[C:5]2[S:14][C:15]([S:17](=[O:20])(=[O:19])[NH2:18])=[CH:16][C:4]=2[NH:3]1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 10359893HCID 10359893, 화합물

생성물 1

HCID 86745510HCID 86745510, 화합물

실험 절차

A mixture of (2,3-dihydro-2,4,4-trioxo-6-sulfamoyl-1H-thieno-[2,3-b][1,4]thiazin-3-yl)acetic acid (5 g) and concentrated sulfuric acid (3 ml) in methanol (50 ml) was heated to reflux for 5 hours. The solvent was removed and the residue was treated with ice cold water. The resulting solid was collected, rinsed with additional cold water and dried at 50° C. to yield 4.05 g. Recrystallization from water gave methyl (2,3-dihydro-2,4,4-trioxo-6-sulfamoyl-1H-thieno-[2,3-b][1,4]thiazin-3-yl)acetate, mp 223°-225° C.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 5 hours
  3. customThe solvent was removed
  4. additionthe residue was treated with ice cold water
  5. customThe resulting solid was collected
  6. washrinsed with additional cold water
  7. customdried at 50° C.
  8. customto yield 4.05 g
  9. customRecrystallization from water

출처 및 근거

ORD 기록
ord-584c26b8131540b495e64e6260ac1c82
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05093332

반응 노트

불러오는 중…