Formaldehyde → 4-fluoro-2-methylamino-benzoic Acid
반응식
[F:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7].[CH2:12]=O.[H][H]>[Pd].C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([NH:11][CH3:12])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7]참가 물질
6
실험 절차
A mixture of 4-fluoroanthranilic acid (2 g), aqueous formaldehyde (37-40% w/v; 6.5 ml) and palladium on charcoal (1 g of 5%) in acetic acid (70 ml) was hydrogenated over 18 hours during which 570 ml hydrogen was taken up. The mixture was filtered, evaporated under reduced pressure and the residue recrystallised from toluene to give 4-fluoro-N-methylanthranilic acid, m.p. 180°-181°. (Compound 7)
후처리
- filtrationThe mixture was filtered
- customevaporated under reduced pressure
- customthe residue recrystallised from toluene
출처 및 근거
- ORD 기록
- ord-1e368b4ec70a43808068c05308364994
- 출처 데이터셋
- uspto-grants-1992_03
- 특허 번호
- US05093364
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