Dimethylformamide → HCID 178514770, 화합물

HRID 237155노트

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HRID 237155 반응식
[NH2:1][CH:2]1[C:25](=[O:26])[N:4]2[C:5]([C:22]([OH:24])=[O:23])=[C:6]([CH:9]([S:16][C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH2:10][CH2:11][S:12](=[O:15])(=[O:14])[NH2:13])[CH2:7][S:8][C@H:3]12.CN(C)C=O.[F:32][C:33]([F:42])([F:41])[CH2:34][S:35]([CH2:37][C:38](O)=[O:39])=[O:36]>C(N(CC)CC)C>[F:32][C:33]([F:42])([F:41])[CH2:34][S:35]([CH2:37][C:38]([NH:1][CH:2]1[C:25](=[O:26])[N:4]2[C:5]([C:22]([OH:24])=[O:23])=[C:6]([CH:9]([S:16][C:17]3[NH:18][N:19]=[N:20][N:21]=3)[CH2:10][CH2:11][S:12](=[O:14])(=[O:15])[NH2:13])[CH2:7][S:8][C@H:3]12)=[O:39])=[O:36]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 205740232-(2,2,2-Trifluoroethanesulfinyl)acetic acidHCID 178508099HCID 178508099, 화합물

생성물 1

HCID 178514770HCID 178514770, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A suspension of 4.17 g. (0.01 mol.) of 7-amino-3-[1-(2-sulfamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid in 50 ml. of dry dimethylformamide is treated with 2 ml. of triethylamine and the mixture is stirred for 15 minutes at 25°. A slight excess of 0.01 mol. of the activated ester of 2,2,2-trifluoroethylsulfinylacetic acid is added to the mixture and it is stirred an additional hour. The reaction mixture is evaporated to dryness and water and ethyl acetate are added to the residue. The layers are separated, ethyl acetate is added to the aqueous phase and it is acidified to pH 2.5 by addition of 6 N hydrochloric acid. The mixture is filtered, the layers are separated and the aqueous phase is extracted with ethyl acetate. The extract is washed with water, dried (MgSO4) and evaporated to dryness to give the title compound.

후처리

  1. additionA suspension of 4.17 g
  2. customThe reaction mixture is evaporated to dryness and water and ethyl acetate
  3. additionare added to the residue
  4. customThe layers are separated
  5. additionethyl acetate is added to the aqueous phase and it
  6. additionis acidified to pH 2.5 by addition of 6 N hydrochloric acid
  7. filtrationThe mixture is filtered
  8. customthe layers are separated
  9. extractionthe aqueous phase is extracted with ethyl acetate
  10. washThe extract is washed with water
  11. dry with materialdried (MgSO4)
  12. customevaporated to dryness

출처 및 근거

ORD 기록
ord-2f1c09c5c1f7439fa40b716676ef9bfd
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159373

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