diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 3,4-dihydro-7-[3-(2-propylphenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid
반응식
[CH2:1]([C:4]1[CH:42]=[CH:41][CH:40]=[CH:39][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:35]=[CH:34][C:14]2[C:15](=[O:33])[CH2:16][C:17]([CH2:26][CH2:27][C:28]([O:30]CC)=[O:29])([CH2:19][CH2:20][C:21]([O:23]CC)=[O:22])[O:18][C:13]=2[C:12]=1[CH2:36][CH2:37][CH3:38])[CH2:2][CH3:3].ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>>[CH2:1]([C:4]1[CH:42]=[CH:41][CH:40]=[CH:39][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:35]=[CH:34][C:14]2[C:15](=[O:33])[CH2:16][C:17]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[O:18][C:13]=2[C:12]=1[CH2:36][CH2:37][CH3:38])[CH2:2][CH3:3]참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared by the method of Example 22 substituting the title product of Example 40 (446 mg) for the title product of Example 21. Crystallization from ethyl acetate/hexane produced 252 mg as a solid, m.p. 163°-165° C.