Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methyl-DL-aspartic acid → N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methyl-DL-aspartic acid | HCID 852 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid | HCID 290744 | 100.8% |
반응 단계
Using a similar method to above 3-methyl-D,L-aspartic acid (10.0 g, 67 mmol), benzyl chloroformate (12 ml, 100 mmol) in 50% NaOH (16.7 g, 208 mmol) in water (125 ml) yielded N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid 19.0g as a low melting solid. 1H NMR (90 MHz, CDCl3 /d6DMSO): δ1.1 (3,d), 2.9 (1,dt), 4.4 (1,m), 4.95 (2,s) 5.9 (1,bd) 7.2 (5,6) 7.9 (1,bs).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05095009 |
| 출처 데이터셋 | uspto-grants-1992_03 |
| ORD ID | ord-40ba4377061848d0aefb87629504ce54 |
| 출처 메모 | uspto-grants-1992_03 |