Ammonium Hydroxide → HCID 15042212, 화합물

HRID 2371741노트

반응식

HRID 2371741 반응식
[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[OH-].[NH4+:18]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH2:18])=[O:10])[CH2:6]1

참가 물질

5

반응물 2

HCID 14923Ammonium HydroxideHCID 199062193-(2,4-Dichlorophenoxy)-1-azetidinecarbonyl chloride

생성물 1

HCID 15042212HCID 15042212, 화합물수율 87.9%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A stirred solution of 4.8 g (0.017 mole) of 3-(2,4-dichlorophenoxy)-1-azetidinecarbonyl chloride in 20 mL of tetrahydrofuran was treated with 3.0 mL (0.05 mole) of 57% ammonium hydroxide. After stirring for 5 h, the reaction mixture was diluted with 200 mL of water and the precipitated solid collected by filtration (4.1 g). The crude product was recrystallized from acetonitrile/water to yield 3.9 g (87.9%) of white crystals, mp 169°-170° C.

후처리

  1. filtrationthe precipitated solid collected by filtration (4.1 g)
  2. customThe crude product was recrystallized from acetonitrile/water

출처 및 근거

ORD 기록
ord-8a451f886de543d88136bbef2c1cdb22
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05095014

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