Acetone → 4-((3-Methacrylamidopropyl)dimethylammonio)butane-1-sulfonate

HRID 237187

반응식

HRID 237187 반응식
[CH3:1][N:2]([CH3:12])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:11])[C:8]([CH3:10])=[CH2:9].[CH2:13]1[S:18](=[O:20])(=[O:19])[O:17][CH2:16][CH2:15][CH2:14]1.CC(C)=O.CO>C(#N)C>[S:18]([CH2:13][CH2:14][CH2:15][CH2:16][N+:2]([CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:11])[C:8]([CH3:10])=[CH2:9])([CH3:12])[CH3:1])([O-:17])(=[O:20])=[O:19]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 887MethanolHCID 154111,4-Butane sultoneHCID 78882N-(3-(Dimethylamino)propyl)methacrylamide

생성물 1

HCID 866625434-((3-Methacrylamidopropyl)dimethylammonio)butane-1-sulfonate수율 85.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
70 °C

실험 절차

In 380 ml of acetonitrile were dissolved 130 g (0.764 mol) of N-[3-(dimethylamino)propyl]methacrylamide, 104 g of butanesultone and 234 mg of 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy and the solution was heated at 70° C. for 6 hours. After allowing to cooling, to the reaction mixture were added 1,350 ml of acetone and 150 ml of methanol and the mixture was stirred at room temperature for one hour. The crystals deposited were collected by filtration and thoroughly washed with acetone to obtain 200.0 g (yield: 85%) of 4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium.

후처리

  1. temperatureto cooling, to the reaction mixture
  2. filtrationThe crystals deposited were collected by filtration
  3. washthoroughly washed with acetone

출처 및 근거

ORD 기록
ord-934bc97a98874649a165d5e8a6cf5c39
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642243B2

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